Article
Functional tuning of photoactive yellow protein by active site residue 46.
Biochemistry - 30 Dec 2008
Philip Andrew F, Eisenman Kaury T, Papadantonakis George A, Hoff Wouter D
Abstract excerpt
Protein-ligand interactions alter the properties of active site groups to achieve specific biological functions. The active site of photoactive yellow protein (PYP) provides a model system for studying such functional tuning. PYP is a small bacterial photoreceptor with photochemistry based on its p-coumaric acid (pCA) chromophore. The absorbance maximum and pK(a) of the pCA in the active site of native PYP are...
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