Article
Capturing the photo-signaling state of a photoreceptor in a steady-state fashion by binding a transition metal complex.
Protein science : a publication of the Protein Society - 1 Nov 2017
Yu Pengyun, Song Lei, Qin Jun, Wang Jianping
Abstract excerpt
Binding a small molecule to proteins causes conformational changes, but often to a limited extent. Here, we demonstrate that the interaction of a CO-releasing molecule (CORM3) with a photoreceptor photoactive yellow protein (PYP) drives large structural changes in the latter. The interaction of CORM3 and a mutant of PYP, Met100Ala, not only trigger the isomerization of its chromophore, p-coumaric acid, from its...
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