Article

Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer’s disease risk

2026-02-12

Abstract excerpt

<title>Abstract</title> <p>Menopause is a hallmark process in biological aging that has been associated with later life neurodegenerative risk. We leveraged proteomics data from multiple cohorts (N>3,000) to identify biological changes underlying menopause and its links to brain aging. In N=80 rigorously-phenotyped pre-, peri-, and postmenopausal women with serum NULISAseq proteomics, spontaneous menopause was ch...

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Literature Corpus work: dfffb72c-8b3b-5948-8c06-ce061839d9c3
DOI: 10.21203/rs.3.rs-8752767/v1

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