Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone.

Journal of medicinal chemistry - 22 Jan 2009

Chimenti Franco, Bizzarri Bruna, Maccioni Elias, Secci Daniela, Bolasco Adriana, Chimenti Paola, Fioravanti Rossella, Granese Arianna, Carradori Simone, Tosi Federica, Ballario Paola, Vernarecci Stefano, Filetici Patrizia

Abstract excerpt

Acetylation is a key modulator of genome accessibility through decondensation of the chromatin structure. The balance between acetylation and opposite deacetylation is, in fact, a prerequisite for several cell functions and differentiation. To find modulators of the histone acetyltransferase Gcn5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Glutamic Acid

Share to Histone Acetyltransferases

Share to Histones

Share to Saccharomyces cerevisiae Proteins

Share to Thiazoles

Source

Identifiers

PMID: 19099397
DOI: 10.1021/jm800885d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19099397-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone.PMID 19099397Read ↗

A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida SpeciesSemantic proximity Read ↗

CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia CellsSemantic proximity Read ↗

Chemogenomic profiling of the cellular effects associated with histone H3 acetylation impairment by a quinoline-derived compound.Semantic proximity Read ↗

High throughput screening identifies modulators of histone deacetylase inhibitors.Semantic proximity Read ↗

Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional connection between histone acetyltransferase Gcn5p and methyltransferase Hmt1p.Semantic proximity Read ↗

Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell linesSemantic proximity Read ↗

Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae.Semantic proximity Read ↗

Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis.Semantic proximity Read ↗

ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.