Article
Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects.
Cancer - 15 Mar 2008
Ross Joy R, Riley Julia, Taegetmeyer Annie B, Sato Hiroe, Gretton Sophy, du Bois Roland M, Welsh Kenneth I
Abstract excerpt
BACKGROUND: Pain is a common symptom for patients with cancer, and opioids are the treatment of choice for moderate or severe cancer-related pain. Central side effects, such as drowsiness, confusion, and hallucinations, can limit the use of opioids in clinical practice. METHODS: The authors prospectively recruited 228 cancer patients who received morphine. Clinical data, including pain and side-effect scores,...
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