Article
Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2009
Dalmau Judith, Puertas Maria Carmen, Azuara Marta, Mariño Ana, Frahm Nicole, Mothe Beatriz, Izquierdo-Useros Nuria, Buzón Maria José, Paredes Roger, Matas Lourdes, Allen Todd M, Brander Christian, Rodrigo Carlos, Clotet Bonaventura, Martinez-Picado Javier
Abstract excerpt
BACKGROUND: During acute human immunodeficiency virus (HIV) infection, high viral loads and the induction of host immune responses typically coincide with the onset of clinical symptoms. However, clinically severe presentations during acute HIV type 1 (HIV-1) infection, including AIDS-defining symptoms, are unusual. METHODS: Virus isolates were tested for clade, drug susceptibility, coreceptor use, and growth...
Topics
- Adolescent
- Adult
- Cells, Cultured
- Female
- Genotype
- HIV Antibodies
- HIV Infections
- HIV-1
- HLA Antigens
- Humans