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Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians.

Pharmacogenetics and genomics - 1 Oct 2009

Sharma Shruti, Das Mitashree, Kumar Ashok, Marwaha Vishal, Shankar Subramanian, Singh Paramjeet, Raghu Padmanabhan, Aneja Ritu, Grover Rahul, Arya Vivek, Dhir Varun, Gupta Rajiva, Kumar Uma, Juyal Ramesh C, K Thelma B

Abstract excerpt

OBJECTIVE: Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed to clinical heterogeneity and genetic variations influencing MTX pharmacology. In this study, we analyzed the association of polymorphisms in ATIC, AMPD1, ADA, and ADORA2A from the purine biosynthetic pathway with MTX response in RA patients from north India. We also assessed the...

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Source

Identifiers

PMID: 19902562
DOI: 10.1097/fpc.0b013e328331b53e

Genes

ADA
FPGS
TYMS
AMPD1
ATIC
DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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