Article
Genetic Variants Increasing TAS2R38 Bitter Taste Receptor Sensitivity Are Associated With Lower Postprandial Glycemia.
Diabetes - 1 Dec 2025
Gervis Julie E, Westerman Kenneth E, Cole Joanne B, Merino Jordi, Cromer Sara J, Udler Miriam S
Abstract excerpt
TAS2R38 is a bitter taste receptor that influences bitter taste perception and diet and is also found in intestinal L cells that store and secrete glucagon-like peptide 1 (GLP-1). Preclinical studies have linked TAS2R38 activation to postprandial GLP-1 secretion, fueling interest in TAS2R38 as a therapeutic target for glucose regulation; however, evidence in humans remains limited. To further establish TAS2R38...
Topics
- Humans
- Receptors, G-Protein-Coupled
- Taste Receptors, Type 2
- Blood Glucose
- Postprandial Period
- Male
- Middle Aged
- Female
- Haplotypes
- Taste
- Adult