Article
A novel approach to syncopal patients: association analysis of polymorphisms in G-protein genes and tilt outcome.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Jan 2009
Lelonek Malgorzata, Pietrucha Tadeusz, Matyjaszczyk Monika, Goch Jan Henryk
Abstract excerpt
AIMS: G-proteins signal transduction pathways play a basic role in cardiovascular reflexes. We hypothesized that the predisposition to reflex-mediated syncope may be associated with genetic variations in G-protein genes. The aim of this study was to evaluate the effect of three single-nucleotide polymorphisms in G-protein genes on tilting outcome in syncopal patients. METHODS AND RESULTS: A total of 217 syncopal...
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