Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the parasympathetic signaling pathway in patients with reflex syncope.

Genetics and molecular research : GMR - 30 Jan 2013

Holmegard H N, Benn M, Mehlsen J, Haunsø S

Abstract excerpt

Reflex syncope is defined by a self-terminating transient loss of consciousness associated with an exaggerated response of the vagal reflexes upon orthostatic challenges. A hereditary component has previously been suggested. We hypothesized that variations in genes encoding proteins mediating the vagal signaling in the heart may be involved in reflex syncope pathogenesis. We systematically resequenced the entire...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to KCNJ5 gene

Share to Genetic Association Studies

Share to GTP-Binding Protein beta Subunits

Share to Polymorphism, Single Nucleotide

Share to Receptor, Muscarinic M2

Source

Identifiers

PMID: 23408450
DOI: 10.4238/2013.January.30.6

Genes

KCNJ5
CHRM2
GNB1
GNG2
KCNJ3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the parasympathetic signaling pathway in patients with reflex syncope.PMID 23408450Read ↗

Genetic variants associated with syncope implicate neural and autonomic processesSemantic proximity Read ↗

Towards Understanding the Genetic Nature of Vasovagal Syncope.Semantic proximity Read ↗

Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K + Channel) Channel FunctionSemantic proximity Read ↗

Genetic variation in the inwardly rectifying K channel subunits KCNJ3 (GIRK1) and KCNJ5 (GIRK4) in patients with sinus node dysfunction.Semantic proximity Read ↗

[Genetics in neurocardiogenic syncope].Semantic proximity Read ↗

Genetic insight into syncopal tilted population with severe clinical presentation.Semantic proximity Read ↗

Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality.Semantic proximity Read ↗

Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope.Semantic proximity Read ↗

Risk Factors for Syncope Associated With Multigenerational Relatives With a History of Syncope.Semantic proximity Read ↗

Vasovagal Syncope Is Associated with Variants in Genes Involved in Neurohumoral Signaling Pathways.Semantic proximity Read ↗

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.Semantic proximity Read ↗

Genetic basis of autonomic dysfunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.