Article
Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2009
Gow C-H, Chang Y-L, Hsu Y-C, Tsai M-F, Wu C-T, Yu C-J, Yang C-H, Lee Y-C, Yang P-C, Shih J-Y
Abstract excerpt
BACKGROUND: Mutations of the epidermal growth factor receptor (EGFR) gene in non-small-cell lung cancer (NSCLC) patients predict the patients who will respond to EGFR tyrosine kinase inhibitor (TKI) treatment. A recent study has suggested that 33% of NSCLC showed primary tumor/metastasis discordance of EGFR expression by immunohistochemistry analysis. We intended to find out whether the EGFR mutations of primary...
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