Article
EGFR mutation status in primary lung adenocarcinomas and corresponding metastatic lesions: discordance in pleural metastases.
Clinical lung cancer - 1 Nov 2011
Han Hye-Suk, Eom Dae-Woon, Kim Joo Heon, Kim Kyung-Hee, Shin Hyang-Mi, An Jin Young, Lee Ki Man, Choe Kang Hyeon, Lee Ki Hyeong, Kim Seung Taik, Koo Ji Hae, Lee Ho-chang, Lee Ok-Jun
Abstract excerpt
UNLABELLED: We evaluated EGFR and KRAS mutations between 37 paired primary tumors and corresponding metastases in lung adenocarcinoma. A substantial discordance was found in EGFR mutation status between primary tumors and corresponding metastases including pleural metastases. Moreover, the responsiveness to EGFR tyrosine kinase inhibitors tend to be correlated with EGFR mutation status in metastatic lesions than...
Topics
- Adenocarcinoma
- Adrenal Gland Neoplasms
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
- Biomarkers, Tumor
- Bone Neoplasms
- Brain Neoplasms
- Carcinoma, Non-Small-Cell Lung