Article
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
International journal of molecular sciences - 7 Apr 2016
Rau Kun-Ming, Chen Han-Ku, Shiu Li-Yen, Chao Tsai-Ling, Lo Yi-Ping, Wang Chin-Chou, Lin Meng-Chih, Huang Chao-Cheng
Abstract excerpt
Mutations on epidermal growth factor receptor (EGFR) of adenocarcinomas of lung have been found to be associated with increased sensitivity to EGFR tyrosine kinase inhibitors and K-ras mutations may correlate with primary resistance. We aimed to explore the discordant mutation statuses of EGFR and K-ras between primary tumors and matched brain metastases in adenocarcinomas of lung. We used a sensitive Scorpion...
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