Article
Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB.
Molecular microbiology - 1 Sept 2014
Abdullah Mohammed R, Gutiérrez-Fernández Javier, Pribyl Thomas, Gisch Nicolas, Saleh Malek, Rohde Manfred, Petruschka Lothar, Burchhardt Gerhard, Schwudke Dominik, Hermoso Juan A, Hammerschmidt Sven
Abstract excerpt
Bacterial cell wall hydrolases are essential for peptidoglycan turnover and crucial to preserve cell shape. The d,d-carboxypeptidase DacA and l,d-carboxypeptidase DacB of Streptococcus pneumoniae function in a sequential manner. Here, we determined the structure of the surface-exposed lipoprotein DacB. The crystal structure of DacB, radically different to that of DacA, contains a mononuclear Zn(2+) catalytic...
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