Article
The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: reconstitution of skin fibrosis development using a tissue engineering approach.
The Journal of pathology - 1 Mar 2009
Corriveau Marie-Pier, Boufaied Inès, Lessard Julie, Chabaud Stéphane, Senécal Jean-Luc, Grodzicky Tamara, Chartier Suzanne, Raymond Yves, Moulin Véronique J
Abstract excerpt
We set out to examine the pathophysiological mechanisms of fibrosis in diffuse systemic sclerosis (SSc) using a tissue engineering approach. Skin fibroblasts were isolated from lesional skin of SSc patients with a disease duration of less than 1 year (early-stage SSc) or more than 10 years (late-...
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