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Article

N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma.

QJM : monthly journal of the Association of Physicians - 1 Jul 2005

Dziadzio M, Usinger W, Leask A, Abraham D, Black C M, Denton C, Stratton R

Abstract excerpt

BACKGROUND: Over-expression of connective tissue growth factor (CTGF) is a hallmark of fibrotic disease, including scleroderma. CTGF acts with the pro-fibrotic cytokine TGFbeta to promote sustained fibrotic responses in vivo. Elevated production of CTGF might be responsible for maintenance of the...

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Identifiers

PMID: 15955800
DOI: 10.1093/qjmed/hci078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15955800-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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