Article
Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice?
Research in immunology - 1 Feb 1991
Starobinas N, Russo M, Minoprio P, Hontebeyrie-Joskowicz M
Abstract excerpt
Early wasting and subsequent mortality may occur in mice of some inbred strains following infection with Trypanosoma cruzi. It was hypothesized that TNF alpha/cachectin might be involved in this process. Thus, sera collected from mice of strains differing in their susceptibility or resistance to Trypanosoma cruzi infection were checked for the presence and level of TNF alpha, a cytokine able to exert acute toxic...
Topics
- Acute Disease
- Animals
- Chagas Disease
- Genetic Predisposition to Disease
- Macrophages
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Species Specificity