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Article

Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response.

Acta tropica - 1 Jan 2000

Naessens Jan, Kitani Hiroshi, Momotani Eiichi, Sekikawa Kenji, Nthale Joseph M, Iraqi Fuad

Abstract excerpt

C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and with survival time. Absence of TNF-alpha resulted in a diminished capacity to form germinal centres in lymph nodes and...

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Source

Identifiers

PMID: 15533287
DOI: 10.1016/j.actatropica.2004.05.015

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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