Studies of concanavalin A in nonobese diabetic mice. I. Prevention of insulin-dependent diabetes.

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Article

Studies of concanavalin A in nonobese diabetic mice. I. Prevention of insulin-dependent diabetes.

The Journal of pharmacology and experimental therapeutics - 1 Aug 1991

Pearce R B, Peterson C M

Abstract excerpt

Concanavalin A (Con A) administered in vivo inhibited the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic mice. By experimental day 310 only one of 10 Con A-treated animals had developed IDDM compared to six of 11 cohort controls receiving buffered saline and 65% of...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
Blood Glucose
CD4 Antigens
CD8 Antigens
Concanavalin A
Diabetes Mellitus, Type 1
Female
Lymphocyte Activation
Lymphocytes
Mice
Mice, Inbred C57BL
Pancreas
Phenotype

Source

Open in PubMed

Identifiers

PMID: 1907661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1907661-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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