Article
Type 1 diabetes: chronic progressive autoimmune disease.
Novartis Foundation symposium - 1 Jan 2008
Zhang Li, Gianani Roberto, Nakayama Maki, Liu Edwin, Kobayashi Masakazu, Baschal Erin, Yu Liping, Babu Sunanda, Dawson Abby, Johnson Kelly, Jahromi Mohamed, Aly Theresa, Fain Pamela, Barker Jennifer, Rewers Marian, Eisenbarth George S
Abstract excerpt
A wealth of data in animal models indicates that type 1A diabetes results from T cell-mediated specific destruction of islet beta cells. There is evidence for the NOD mouse model that insulin is the primary autoantigen and a specific insulin peptide B:9-23 is central to pathogenesis. It is also now possible to predict the development of type 1A (immune mediated) diabetes for the great majority of individuals with...
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