Aging perturbs 26S proteasome assembly in <i>Drosophila melanogaster</i>

Abstract excerpt

Aging is associated with loss of quality control in protein turnover. The ubiquitin-proteasome pathway is critical to this quality control process as it degrades mutated and damaged proteins. We identified a unique aging-dependent mechanism that contributes to proteasome dysfunction in Drosophila melanogaster. Our studies are the first to show that the major proteasome form in old (43-47 days old) female and male...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Genetics and Neurodevelopmental Disorders
• Share to Ubiquitin and proteasome pathways