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Article

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor.

Cancer research - 1 Mar 2006

Rankin Erinn B, Tomaszewski John E, Haase Volker H

Abstract excerpt

Inactivation of the von Hippel-Lindau tumor suppressor, pVHL, is associated with both hereditary and sporadic renal cysts and renal cell carcinoma, which are commonly thought to arise from the renal proximal tubule. pVHL regulates the protein stability of hypoxia-inducible factor (HIF)-alpha subunits and loss of pVHL function leads to HIF stabilization. The role of HIF in the development of VHL-associated renal...

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Share to Kidney Diseases, Cystic

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Source

Open in PubMed Open full text

Identifiers

PMID: 16510575
DOI: 10.1158/0008-5472.CAN-05-3241
PMCID: PMC3514875

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor.PMID 16510575Read ↗

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