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Article

Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes.

The Journal of biological chemistry - 5 Aug 1991

Manchanda N, Schwartz B S

Abstract excerpt

Cellular migration typically requires cell surface-associated urokinase-type plasminogen activator (u-PA) and plasminogen, both of which are present as proenzymes. Because each active enzyme can activate the other zymogen, the mechanism by which the initial proteolytic event of this two-zymogen system occurs is unclear. A mutant of single chain u-PA that could not be cleaved to the more active two-chain u-PA was...

Topics

Autoradiography
Enzyme Precursors
Fibrinolysis
Humans
Hydrolysis
Monocytes
Mutation
Plasminogen Activators
Serine
Urokinase-Type Plasminogen Activator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1907280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1907280-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes.PMID 1907280Read ↗

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