Article
Differential inhibition of soluble and cell surface receptor-bound single-chain urokinase by plasminogen activator inhibitor type 2. A potential regulatory mechanism.
The Journal of biological chemistry - 18 Mar 1994
Schwartz B S
Abstract excerpt
Urokinase (u-PA)-mediated cell surface plasminogen activation is required for cellular tissue invasion. This invasion occurs in environments rich in plasminogen activator inhibitors (PAIs), which efficiently inhibit receptor-bound two-chain u-PA. Single-chain u-PA (scu-PA) was recently found to e...
Topics
- Amino Acid Sequence
- Cell Membrane
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- Glutamates
- Glutamic Acid
- Humans
- Kinetics
- Models, Biological
- Plasminogen
- Plasminogen Activator Inhibitor 2
- Receptors, Cell Surface