Article
CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.
Brain research - 28 Jan 2009
Noguchi-Shinohara Moeko, Tokuda Takahiko, Yoshita Mitsuhiro, Kasai Takashi, Ono Kenjiro, Nakagawa Masanori, El-Agnaf Omar M A, Yamada Masahito
Abstract excerpt
Dementia with Lewy bodies (DLB) is characterized by widespread depositions of alpha-synuclein, which are described as Lewy bodies. Recently, it was shown that neuronal cells in culture constitutively release alpha-synuclein into the culture medium and that alpha-synuclein is normally present in human cerebrospinal fluid (CSF). The aim of the present study was to evaluate the diagnostic value of CSF...
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