Article
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology - 1 Nov 1998
Lippa C F, Fujiwara H, Mann D M, Giasson B, Baba M, Schmidt M L, Nee L E, O'Connell B, Pollen D A, St George-Hyslop P, Ghetti B, Nochlin D, Bird T D, Cairns N J, Lee V M, Iwatsubo T, Trojanowski J Q
Abstract excerpt
Missense mutations in the alpha-synuclein gene cause familial Parkinson's disease (PD), and alpha-synuclein is a major component of Lewy bodies (LBs) in sporadic PD, dementia with LBs (DLB), and the LB variant of Alzheimer's disease (AD). To determine whether alpha-synuclein is a component of LBs in familial AD (FAD) patients with known mutations in presenilin (n = 65) or amyloid precursor protein (n = 9) genes,...
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