Article
Genetic profiling of human cell lines used as in vitro model to study cardiovascular pathophysiology and pharmacotoxicology.
Cell biology and toxicology - 1 Dec 2009
Jeannesson Elise, Siest Gérard, Zaiou Mohamed, Berrahmoune Hind, Masson Christine, Visvikis-Siest Sophie
Abstract excerpt
BACKGROUND: Cell lines are widely used to monitor drug pharmacokinetics and pharmacodynamics and to investigate a number of biochemical mechanisms. However, little is known about the genetic profile of these in vitro models. OBJECTIVES: To analyze genetic profile of Thp1, U937, HL60, K562, HepG2, Kyn2, and Caco2 human cell lines with a focus on genetic variations within genes involved in the development of...
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