Article
Statin response and pharmacokinetics variants.
Expert opinion on pharmacotherapy - 1 Jul 2005
Kajinami Kouji, Masuya Hiroshi, Hoshiba Yachiyo, Takeda Kenji, Sato Ryoko, Okabayashi Mizuho, Schaefer Ernst J
Abstract excerpt
Despite statin therapy being effective in the primary and secondary prevention of coronary heart disease, the benefit of treatment varies between individuals. Interindividual variations in pharmacokinetics play a central role in the cause of variability of drug disposition, and, in turn, the drug's clinical efficacy. Exploring genetic variations that influence pharmacokinetics may lead clinicians to apply the...
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