Article
Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.
Cell - 13 Dec 2002
Myat Monn Monn, Andrew Deborah J
Abstract excerpt
Formation of tubes of the correct size and shape is essential for viability of most organisms, yet little is understood of the mechanisms controlling tube morphology. We identified a new allele of hairy in a mutagenesis screen and showed that hairy mutations cause branching and bulging of the normally unbranched salivary tube, in part through prolonged expression of huckebein (hkb). HKB controls polarized cell...
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