Article
Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation.
Toxicology and applied pharmacology - 15 Feb 2009
Jensen Taylor J, Wozniak Ryan J, Eblin Kylee E, Wnek Sean M, Gandolfi A Jay, Futscher Bernard W
Abstract excerpt
Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling pathways and aberrant epigenetic regulation. We initiated studies to examine the role of a member of the non-canonical WNT signaling pathway, WNT5A, in UROtsa cells...
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