Article
FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease.
Genome biology - 1 Jan 2008
Chen Rong, Morgan Alex A, Dudley Joel, Deshpande Tarangini, Li Li, Kodama Keiichi, Chiang Annie P, Butte Atul J
Abstract excerpt
BACKGROUND: Candidate single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWASs) were often selected for validation based on their functional annotation, which was inadequate and biased. We propose to use the more than 200,000 microarray studies in the Gene Expression Omnibus to systematically prioritize candidate SNPs from GWASs. RESULTS: We analyzed all human microarray studies from the...
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