Article

Prioritizing disease-related rare variants by integrating gene expression data

2024-05-10

Abstract excerpt

<title>Abstract</title> <p>Rare variants, comprising a vast majority of human genetic variations, are likely to have more deleterious impact on human diseases compared to common variants. Here we present carrier statistic, a statistical framework to prioritize disease-related rare variants by integrating gene expression data. By quantifying the impact of rare variants on gene expression, carrier statistic can pri...

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Literature Corpus work: 91959eeb-b8e5-58c0-b8a9-62b8782f79a6
DOI: 10.21203/rs.3.rs-4355589/v1

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