Article
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.
The EMBO journal - 2 Sept 2002
Petrova Tatiana V, Mäkinen Taija, Mäkelä Tomi P, Saarela Janna, Virtanen Ismo, Ferrell Robert E, Finegold David N, Kerjaschki Dontscho, Ylä-Herttuala Seppo, Alitalo Kari
Abstract excerpt
Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption, and also serve as a major route for tumor metastasis in many types of cancer. We found that isolated human primary lymphatic and blood vascular endothelial cells (LECs and BECs, respectively) show interesting differences in gene expression relevant for their distinct functions in vivo. Although these phenotypes are...
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