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Article

Effects of long-term<i>in vitro</i>cultivation on the virulence of cloned lines of<i>Leishmania major</i>promastigotes

1 Jan 1992

Abstract excerpt

The virulences of several clones from a single Leishmania major strain were studied in BALB/c mice. Clones showed the same pattern of infectivity and virulence two months after cloning as the parental population. After prolonged in vitro culture, however, it was apparent that two types of virulent clones existed: although the level of virulence remained stable in some clones, in others, such as C-11, it...

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PMID: 1463354
DOI: 10.1080/00034983.1992.11812677

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