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Article

Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis.

European journal of immunology - 1 Jan 2009

Kumari Shraddha, Samant Mukesh, Khare Prashant, Misra Pragya, Dutta Sujoy, Kolli Bala Krishna, Sharma Sharad, Chang Kwang Poo, Dube Anuradha

Abstract excerpt

Leishmania, naturally residing in the phagolysosomes of macrophages, is a suitable carrier for vaccine delivery. Genetic complementation of these trypanosomatid protozoa to partially rectify their defective heme-biosynthesis renders them inducible with delta-aminolevulinate to develop porphyria for selective photolysis, leaving infected host cells unscathed. Delivery of released "vaccines" to antigen-presenting...

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Identifiers

PMID: 19053149
DOI: 10.1002/eji.200838389
PMCID: PMC5056643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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