Safety, immunogenicity, and efficacy of a gentamicin-attenuated Leishmania major vaccine in an open-label clinical vaccine trial

Abstract excerpt

<title>Abstract</title> <p>An attenuated line of Leishmania major was generated by culturing promastigotes in vitro in the presence of gentamicin. Preclinical studies demonstrated that this strain was safe and capable of inducing cellular immunity. The present study evaluated the safety and immunogenicity of the gentamicin-attenuated L. major (GALM) vaccine in 27 human subjects. Safety was assessed through advers...

Topics

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• Monoclonal and Polyclonal Antibodies Research
• Research on Leishmaniasis Studies
• Toxoplasma gondii Research Studies
• Trypanosoma species research and implications
• vaccines and immunoinformatics approaches
• Vector-Borne Animal Diseases
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

7e3cdcfd-bed9-575c-a38d-2f868251a54f

DOI

10.21203/rs.3.rs-8779695/v1