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Article

Diverse and newly recognized effects associated with short interfering RNA binding site modifications on the Tomato bushy stunt virus p19 silencing suppressor.

Journal of virology - 1 Mar 2009

Hsieh Yi-Cheng, Omarov Rustem T, Scholthof Herman B

Abstract excerpt

The Tomato bushy stunt virus-encoded P19 forms dimers that bind duplex short interfering RNAs (siRNAs) to suppress RNA silencing. P19 is also involved in multiple host-specific activities, including the elicitation of symptoms, and in local and/or systemic spread. To study the correlation between those various roles and the siRNA binding by P19, predicted siRNA-interacting sites were modified. Twenty-two mutants...

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Identifiers

PMID: 19052093
DOI: 10.1128/JVI.02186-08
PMCID: PMC2643727

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Source receipt: pubmed, retrieved 7 Sept 2026.

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