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Article

Recognition mechanism of siRNA by viral p19 suppressor of RNA silencing: a molecular dynamics study.

Biophysical journal - 4 Mar 2009

Xia Zhen, Zhu Zhihong, Zhu Jun, Zhou Ruhong

Abstract excerpt

The p19 protein (p19) encoded from Tombusvirus is involved in various activities such as pathogenicity and virus transport. Recent studies have found that p19 is a plant suppressor of RNA silencing, which binds to short interfering RNAs (siRNAs) with high affinity. We use molecular dynamics (MD) simulations of the wild-type and mutant p19 protein (W39 and W42G) binding with a 21-nt siRNA duplex to study the...

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Identifiers

PMID: 19254536
DOI: 10.1016/j.bpj.2008.11.047
PMCID: PMC2717360

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