Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cells <i>via</i> the disruption of mitochondrial bioenergetics/redox state

Abstract excerpt

Cancer chemoprevention employs agents that block, hinder, or reverse tumorigenesis to prevent malignancy. Several putative cancer chemopreventive agents promote apoptosis in transformed cells initiated in animal carcinogenesis models or identified in human subjects, and/or in tumor cells cultured in vitro. Consequently, apoptosis induction is increasingly valued as a biologically significant anticancer mechanism...

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