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Article

Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population.

International journal of obesity (2005) - 1 Feb 2009

Tenesa A, Campbell H, Theodoratou E, Dunlop L, Cetnarskyj R, Farrington S M, Dunlop M G

Abstract excerpt

BACKGROUND: Common single-nucleotide polymorphism (SNP) variants around the melanocortin 4 receptor (MC4R) gene have recently been associated with obesity risk and insulin resistance. Obesity is a known risk factor for colorectal cancer (CRC) and we hypothesized that there might be a common inherited genetic component. METHODS AND RESULTS: Four of the variants reported earlier were genotyped and tested for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19050674
DOI: 10.1038/ijo.2008.257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population.PMID 19050674Read ↗

The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

Melanocortin 4 Receptor Gene Sequence Analyses in Diverse Populations.Semantic proximity Read ↗

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.Semantic proximity Read ↗

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.Semantic proximity Read ↗

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.Semantic proximity Read ↗

Effect of interactions of polymorphisms in the Melanocortin-4 receptor gene with dietary factors on the risk of obesity and Type 2 diabetes: a systematic review.Semantic proximity Read ↗

The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.Semantic proximity Read ↗

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer.Semantic proximity Read ↗

Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis.Semantic proximity Read ↗

Prevalence and expressivity of loss of function mutations in the Melanocortin 4 Receptor (<i>MC4R</i>) in a UK birth cohortSemantic proximity Read ↗

Common genetic variation near MC4R is associated with waist circumference and insulin resistance.Semantic proximity Read ↗

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.Semantic proximity Read ↗

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