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Article

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer.

Cancer epidemiology - 1 Oct 2016

Yang Baiyu, Thrift Aaron P, Figueiredo Jane C, Jenkins Mark A, Schumacher Fredrick R, Conti David V, Lin Yi, Win Aung Ko, Limburg Paul J, Berndt Sonja I, Brenner Hermann, Chan Andrew T, Chang-Claude Jenny, Hoffmeister Michael, Hudson Thomas J, Marchand Loïc Le, Newcomb Polly A, Slattery Martha L, White Emily, Peters Ulrike, Casey Graham, Campbell Peter T

Abstract excerpt

BACKGROUND: Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. METHODS: In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100kb upstream and 300kb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27449576
DOI: 10.1016/j.canep.2016.07.003
PMCID: PMC5125024

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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