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Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome

2020-02-28

Abstract excerpt

The molecular mechanism that triggers polycystic ovary syndrome (PCOS) is mysterious. Abnormal development of ovarian granulosa cells(GCs) is one of the causes of PCOS. Herein, we carried out RNA-seq to detect the different gene expression levels in ovarian GCs between 3 patients with PCOS and 4 normal controls, and found that Hedgehog signaling pathway(Hh) members, Ihh and Ptch2 were abnormally highly expressed i...

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Literature Corpus work
cfff1587-e2e8-56e3-9db4-f2bde3e7214c
DOI
10.21203/rs.3.rs-15484/v1
Open publication

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Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndromeDOI 10.21203/rs.3.rs-15484/v1
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