Article
TP53 mutations in circulating free DNA from Egyptian patients with non-Hodgkin's lymphoma.
Cancer letters - 18 Mar 2009
Hosny Gihan, Farahat Nahla, Hainaut Pierre
Abstract excerpt
BACKGROUND: P53 protein plays important role in the maintenance of genome stability in mammalian cells; it acts in many processes including cell-cycle checkpoint, DNA repair, apoptosis, and angiogenesis. Mutations of P53 have been reported as common mutations in solid tumours, including non-Hodgkin lymphoma, NHL, and have been implicated in drug resistance, aggression and poor prognosis. Chronic infection with...
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