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Article

Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study.

PloS one - 1 Jan 2008

Edwards Albert O, Fridley Brooke L, James Katherine M, Sharma Anil K, Sharma Anil S, Cunningham Julie M, Tosakulwong Nirubol

Abstract excerpt

Genome-wide association studies (GWASs) assess correlation between traits and DNA sequence variation using large numbers of genetic variants such as single nucleotide polymorphisms (SNPs) distributed across the genome. A GWAS produces many trait-SNP associations with low p-values, but few are replicated in subsequent studies. We sought to determine if characteristics of the genomic loci associated with a trait...

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PMID: 19043567
DOI: 10.1371/journal.pone.0003813
PMCID: PMC2583911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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