Article
Phylogenetic analysis of hepatitis A virus in sera from patients with hepatitis A of various severities.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2009
Fujiwara Keiichi, Kojima Hiroshige, Yonemitsu Yutaka, Yasui Shin, Imazeki Fumio, Miki Makoto, Suzuki Kazuyuki, Sakaida Isao, Okita Kiwamu, Tanaka Eiji, Omata Masao, Yokosuka Osamu
Abstract excerpt
BACKGROUND: We analysed the association of the 5' nontranslated region (5'NTR), nonstructural proteins 2B and 2C of the hepatitis A virus (HAV) genome, whose mutations have previously been shown to be important for enhanced replication in cell culture systems, in order to align all our data and examine whether genomic differences in HAV are responsible for the range of clinical severities. METHODS: Our...
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