Article
Genetic variability within the 5' nontranslated region of hepatitis A virus RNA. Implications for secondary structure and function.
Journal of hepatology - 1 Jan 1991
Brown E A, Day S P, Jansen R W, Lemon S M
Abstract excerpt
The RNA genome of hepatitis A virus (HAV) contains a lengthy and relatively well conserved 5' nontranslated region (5'NTR). In other picornaviruses, the 5'NTR has been shown to have important functions related to the initiation of viral translation and replication of viral RNA, functions which are critically dependent on both primary and secondary RNA structure. We have utilized a phylogenetic approach to...
Topics
- Base Composition
- Base Sequence
- Genetic Variation
- Hepatovirus
- Humans
- Molecular Sequence Data
- Nucleic Acid Conformation
- Protein Biosynthesis
- RNA, Viral
- Thermodynamics