Article
Genetic relatedness of hepatitis A virus strains recovered from different geographical regions.
The Journal of general virology - 1 Jun 1992
Robertson B H, Jansen R W, Khanna B, Totsuka A, Nainan O V, Siegl G, Widell A, Margolis H S, Isomura S, Ito K
Abstract excerpt
A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I to VII). In general, the nucleotide sequence of viruses in different genotypes differs at 15 to 25% of positions within this segment of the genome. Viruses from four of the...
Topics
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- DNA, Viral
- Genetic Variation
- Genotype
- Hepatitis A
- Hepatovirus
- Humans
- Molecular Sequence Data
- Sequence Homology, Nucleic Acid