Article
Hepatitis B virus strains of subgenotype A2 with an identical sequence spreading rapidly from the capital region to all over Japan in patients with acute hepatitis B.
Gut - 1 May 2012
Tamada Yoko, Yatsuhashi Hiroshi, Masaki Naohiko, Nakamuta Makoto, Mita Eiji, Komatsu Tatsuji, Watanabe Yukio, Muro Toyokichi, Shimada Masaaki, Hijioka Taizo, Satoh Takeaki, Mano Yutaka, Komeda Toshiki, Takahashi Masahiko, Kohno Hiroshi, Ota Hajime, Hayashi Shigeki, Miyakawa Yuzo, Abiru Seigo, Ishibashi Hiromi
Abstract excerpt
OBJECTIVE: To examine recent trends of acute infection with hepatitis B virus (HBV) in Japan by nationwide surveillance and phylogenetic analyses. METHODS: During 1991 through 2009, a sentinel surveillance was conducted in 28 national hospitals in a prospective cohort study. Genotypes of HBV were determined in 547 patients with acute hepatitis B. Nucleotide sequences in the preS1/S2/S gene of genotype A and B...
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