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Article

Can pharmacokinetic-pharmacodynamic parameters provide dosing regimens that are less vulnerable to resistance?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Nov 2008

Courvalin P

Abstract excerpt

Dissemination of antibiotic resistance in bacteria is associated with prescription of the corresponding drugs. Various pharmacokinetic-pharmacodynamic parameters have been developed with the intention of reducing the spread of resistance. In this review, it is considered whether dosing regimens based on these parameters can delay this spread. The evolution of bacterial resistance to antibiotics involves two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19040470
DOI: 10.1111/j.1469-0691.2008.02081.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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