Article
Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation.
Human molecular genetics - 1 May 2009
Lei Shu-Feng, Tan Li-Jun, Liu Xiao-Gang, Wang Liang, Yan Han, Guo Yan-Fang, Liu Yao-Zhong, Xiong Dong-Hai, Li Jian, Yang Tie-Lin, Chen Xiang-Ding, Guo Yan, Deng Fei-Yan, Zhang Yin-Ping, Zhu Xue-Zhen, Levy Shawn, Papasian Christopher J, Hamilton James J, Recker Robert R, Deng Hong-Wen
Abstract excerpt
Human stature, as an important physical index in clinical practice and a usual covariate in gene mapping of complex disorders, is a highly heritable complex trait. To identify specific genes underlying stature, a genome-wide association study was performed in 1000 unrelated homogeneous Caucasian subjects using Affymetrix 500K arrays. A group of seven contiguous markers in the region of SBF2 gene (Set-binding...
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